Accelerating the development and delivery of cell and gene-based therapies to patients in early phase clinical trials

The King’s College London and Guy’s and St Thomas’ Advanced Therapies Accelerator provides world-leading and continually developing infrastructure to facilitate the development of advanced therapies. By bringing together a unique combination of research platforms and expertise across King’s College London campuses and Guy’s and St Thomas’ hospital sites in South London, we are accelerating the development and delivery of cell and gene-based therapies to patients in early phase clinical trials.  The Advanced Therapies Accelerator aims to leverage the enormous promise that advanced therapies have for the treatment of severe, hard-to-treat diseases.  The Accelerator has been established following significant investment from Research England and the MRC, BBSRC and LifeArc.

The Advanced Therapies Accelerator comprises the following research platforms across King’s College London and Guy’s and St Thomas’ including those specifically managed by the NIHR Guy’s and St Thomas’ Biomedical Research Centre:

  • MRC/BBSRC/LifeArc Gene Therapy Innovation Hub & KCL Gene Therapy Vector Facility. This comprises:
    • GMP Lentiviral Vector Manufacturing Unit – KCL Denmark Hill site (Rayne Institute)
    • GMP AAV Vector Manufacturing Unit – Guy’s Hospital site (4th floor Tower Wing); operational late 2022
  • BRC GMP Cell Manufacturing Unit for a range of cell therapies, including CAR-T, monocytes, T-Reg and ES-derived cell products – Guy’s Hospital site (15th floor Tower Wing)
  • NIHR Clinical Research Facility – MHRA Phase I accredited Unit – Guy’s Hospital site (15th floor Tower Wing)
  • BRC Process Development Laboratories (commercial and academic facilities) – Guy’s Hospital site (10th floor Tower Wing)
  • BRC stem cell/organoid differentiation facilities Guy’s Hospital site (10th floor Tower Wing)
  • BRC Genomics Platform, including MRC-funded single-cell functional genomics capability – Guy’s Hospital site (10th floor Tower Wing)
  • BRC Flow Cytometry Platform – Guy’s Hospital site (10th floor Tower Wing)
  • KCL Centre for Gene Therapy and Regenerative Medicine, including the Stem Cell Hotel – KCL Guy’s Campus (8 and 28th floor Tower Wing)

The Advanced Therapies Accelerator is facilitating a broad portfolio of advanced therapy development projects, manufacturing campaigns and early phase clinical trials, including:

  • the development of ES-derived photoreceptors for the treatment of retinal disorders,
  • mesenchymal stem cells for the treatment of patients with Epidermolysis Bullosa
  • T-reg cells for the autologous treatment of Crohn’s Disease
  • monocytes for the treatment of lung fibrosis in long COVID patients
  • CAR-T cells for the treatment of solid tumour head and neck cancer.
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GSTT Research Facilities Sept 2020-42

Our cutting edge infrastructure

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GSTT Research Facilities Sept 2020-60

Our world class partnerships

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GMP 2020

Our work

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Our team