Professor Stephen Till, a consultant allergist at Guy’s and St Thomas’ and Professor of Allergy at King’s College London is leading the ARIAS study, sponsored by Revolo Biotherapeutics Ltd. The study is working to assess whether a treatment with a new investigational drug – IRL201104 – could reduce the allergy to grass pollen that causes hay fever symptoms.

Allergies happen when your immune system overreacts to a substance (an allergen such as grass pollen) that would otherwise be harmless. Hay fever, also called allergic rhinitis, affects around 25% of the UK and European population. Its symptoms generally include itchy, runny or stuffy nose and sneezing, and it can have a major impact on quality of life. Current treatment for seasonal grass allergy includes taking over the counter or prescription medications to help reduce the symptoms, but these do not eliminate the allergy.

The Arias study is a double blind randomised trial. This means that participants will be randomised to receive either the investigational drug – IRL201104 or a placebo. All participants will receive six doses of either the investigational drug or the matched placebo over six visits within a 12 week period. All study visits will take place within the world class NIHR Clinical Research Facility at Guy’s and St Thomas’ NHS Foundation Trust.

It is hoped that the study will provide evidence about how the new treatment works, what dosage is optimal to improving outcomes for hay fever sufferers and for how long the treatments needs to be delivered to achieve the desired therapeutic effect.

The study is looking to recruit healthy adults aged between 18 and 65, who suffer from hay fever with peak symptoms in May, June or July. Before enrolling in the study, participants will be provided with detailed information about all study visits and related tests and procedures. If you are eligible to participate in the study, you will receive compensation for your travel expenses.

Anyone interested in participating in the trial is encouraged to visit the ARIAS study website at , where you can find out more about the study and register your interest to take part.

If you have any questions that you would like to discuss with the study team prior to registering your interest to take part, please do get in touch with the team at