An interim analysis of data from Phase III trials published in the Lancet today shows that the ChAdOx1 nCoV-2019 vaccine, developed by University of Oxford and AstraZeneca, administered in two doses, was highly effective. Guy’s and St Thomas’ NHS Foundation Trust is a participating centre in this trial.

The vaccine was 90% effective if administered at a half dose and then at a full dose, or 62% effective if administered in two full doses. The data also showed lower rates of asymptomatic infection in the people who had received the half dose followed by a full dose regimen, which suggests that the vaccine could help to prevent transmission of the virus. Additionally, there were no hospitalised or severe cases of COVID-19 in anyone who received the vaccine.

The research to date has been made possible thanks to the 24,000 volunteers who took part in the trial, and the hard work of the talented teams who delivered the research around the world.

Dr Anna Goodman, consultant in infectious diseases, who is the Principal Investigator for the trial at Guy’s and St Thomas’, said: “Over 400 research, clinical and non-clinical staff supported the delivery of the trial at Guy’s and St Thomas’. We are extremely proud and grateful for every single contribution. It is only because of the selfless commitment of the trial participants and dedication of teams just like ours around the world that this work to help halt the progress of the pandemic has been possible. A sincere thank you to each and every one of you.”

Those who supported the trial at Guy’s and St Thomas’ include:

Participants

All of the 492 participants in the trial at Guy’s and St Thomas’.

Teams

R&D governance team

R&D admin

R&D communications team

Guy’s and St Thomas’ communications team

Essentia support

Procurement team

Pharmacy

The Clinical Research Facility team

Staff Bank

Nursing and midwife staffing tactical

ICU matrons

HIV team

Dental team

Rare Disease Centre team

COVID-19 research team

COVID-19 research reception team

Charitable organisations

The XP support group (https://xpsupportgroup.org.uk/)

DEBRA (https://www.debra.org.uk/)

Guy’s and St Thomas’ Charity (www.gsttcharity.org.uk)

Individuals

Abayomi Fatola

Abigail Burgess

Aidan Haslam

Alexander Emery

Alfie Balston

AliAsad Hashtroudi

Alice Lewin

Alice Sharp

Alina Botgros

Alistair Weir

Alyce Sheedy

Amrit Visvanathan

Amy Day

Amy Holton

Andrea Mazzella

Andreas Ziakas

Andrew Ghobrial

Andrii Boguslavskyi

Anele Waters

Ania Rainbird

Anna Barnard

Anna Black

Anna Perman

Anne Collett

Anoosha Gadiraju

Antonia Lynch

Anya Vlassoff

Araminta Roper

Arthika Surendran

Ashley Sartini

Aysan Koray

Balathas Thirugnanabalan

Beth Jackson

Blair Merrick

Carolyn Hemsley

Cassandra Fairhead

Cassie Fairhead

Charles Wolfe

Charlotte Faint

Charlotte Gibbs

Cherry Paice

Chinenye Orji

Clair Harris

Claire Harrison

Claire O’Neill

Claire Singh

Damir Rafi

Dan Furmedge

Daniel Curley

David Lammas

David Oppenheim

David Wood

Dawn Beaumont-Jewell

Deborah Mundle

Deepali Patel

Deirdre Wallace

Dharsha Shivapatham

Dhruv Sarma

Dionne Gill

Elizabeth Pillay

Elizabeth White

Elliot Byford

Elysia James

Eme Chan

Emilia Gnat

Emma Wayman

Estratios Gerakopoulos

Eunice Jeffs

Eva Klamerus

Fahim Ahmed

Fardusa Hassan

Federica Francia

Federico Borchini

Fiona Hibberts

Franca Morselli

Frances Doyle

Gabriel Lee

George Nintos

Geraldine OHara

Gerry Trillana

Gill Arbane

Gladys Monde

Hayley Tarft

Hazel Honeywell

Hemawtee Sreeneebus

Henry Fok

Hilary Thompson

Holly Lovell

Ian Abbs

Ike Obi

Ilknur Shevket

Imogen Peplow

Jack Kingdon

Jackie Pullen

Jakob Jeriha

James Spicer

James Williams

Jasper Vink

Jayshireen Singh

Jeff Brazel

Jessamine Hunt

JinSun Yoo

Jo Furley

Joan Fleetwood-Joyce

Joan Nanan

Joanne Palmer-Joyce

Johannes Driessen

Jonathan Essex

Joseph Parsons

Joshua Au Yeung

Julie Fox

Julie John

Karen Bisnauthsing

Karen Walker

Karen Wilson

Karina Mahiouz

Kate Blake

Katherine Blackstone

Krzystof Rutkowski

Laura Bremner

Lauren Arnold

Lauren Martinez

Leanna Brace

Linda Gomm

Louise Griffiths

Luca Scott

Luciana Sowole

Lucy Storey

Lydia Gojke

Magdalena Martinez-Queipo

Mai Worthington

Maria Flaquer

Martinez Castrillo

Matea Deliu

Melanie Haines

Moncy Matthew

Mguni Nhlanhla

Mijan Miah

Mike Lyne

Naomi Hare

Natalie Grey

Natalie Page

Natalie Palmer

Natasha Ajraam

Neil Morton

Nick Hart

Nick Price

Nicola McCutcheon

Nicola Varatharajah

Nieves Velazquez

Noelia Pitrelli

Nuria Martinez-Alier

Olanike Okolo

Oluseyi Daropale

Olympia Tsilochirustou

Parizade Raymode

Paul Burdett

Paul Dargan

Paula Darroch

Peter Bennett

Phil Chowienczyk

Rachael Morris-Jones

Rahel Werku

Rajesh Bhooban

Ramesh Thurairaja

Raquel Ihekwoaba

Rashida Pramanik

Rebekah Roberts

Rezaur Rahman

Rhys Brown

Ria Brunton

Richard Love

Rishi Iyer

Rizwana Dakri

Robert Cormack

Robert Sanarky

Roni Cummings

Roser Guiteras

Sahnaj Sultana

Sally Walker

Samantha Broadhead

Samantha Buckner

Samantha Salaver

Sara Jane Lyons

Sarah Betts

Sarah Keegan

Sarah Rodrigues

Sarah Ruiz

Servious Dube

Sharon Whelan

Shaun Cochrane

Shelley Mieres

Shevanti Sandrasagra

Simbiso Maswera

Simon Goldenberg

Sinead O’Dwyer

Sonia Serrano

Stephen Till

Sue Cox

Tammy Davey

Teresa Crowley

Teresa Solano

Tess Cheetham

Tharnitha Vasavan

Thi DieuVu

Thurkka Rajeswaran

Tiago Soares

Tim Borrie

Tom Williams

Vaishali Vyas

Vanessa Parker

William Wells

Yemi Adelaja

Zandile Khumalo

Zareen Bheekhun

Zoe Vowles

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