The Immunity and Infection theme aims to address highly significant local and global health burdens.

The theme maximises its interdisciplinary translational research by integration of the KCL Immunology, Infection and Inflammatory Diseases Division and the clinical units of the Guy’s and St Thomas’ and King’s College Hospital Trusts which form part of the Clinical Academic Grouping in Genetics, Rheumatology, Infection, Immunology, and Dermatology (GRIID) at King’s Health Partners.

Aims

  • Develop advanced therapeutic and experimental medicine strategies delivered through Cluster 1 for autoimmune, inflammatory, infectious and neoplastic diseases;
  • Develop biomarkers and co-diagnostics delivered through Cluster 2 for autoimmune, inflammatory, infectious and neoplastic diseases;
  • Develop disease prevention strategies via phase I/II and biomarker/mechanism-focused studies in non-diabetic children at high risk of T1D;
  • Identify patients with inflammatory arthritis most likely to respond to IL-17 blockade;
  • Investigate basis for HIV persistence during antiretroviral therapy;
  • Apply CAR T-cell immunotherapy to mesothelioma and solid tumours.

Lead

Michael Malim FRS FMedSci

Professor, Infectious Diseases; Head, Division of Immunology, Infection and Inflammatory Disease; Director, MRC-King’s Doctoral Training Partnership in Biomedical Sciences; Wellcome Trust Senior Investigator.