Lead centre trial team

The trial team are based at Guy’s and St Thomas’ NHS Foundation Trust. Find out more about their background and their role in the trial.

Dr Manu Shankar-HariChief Investigator

Dr Manu Shankar-Hari's unique research perspective comes from combining a formal training in epidemiology and basic science (immunology). His translational research focuses on the epidemiology and the adaptive immune system changes in sepsis survivors to inform ways to improve outcomes in this patient population and how to enrich sepsis and ARDS sub-phenotypes for clinical trials. His Epidemiology research focuses on Critical illness Epidemiology; Health Services Research; and Longer-term outcomes from critical illness. Dr Manu Shankar-Hari joined Guy's and St Thomas' critical care team as a consultant physician and clinician researcher in 2009. His area of expertise is critical care medicine, immunology of sepsis, acute organ failure, and epidemiology and study design.

Professor David HarrisonTrial Statistician

Professor David Harrison is Head Statistician at the Intensive Care National Audit & Research Centre (ICNARC), responsible for overseeing all statistical aspects of ICNARC’s broad programme of clinical audit and research. David graduated from the University of Cambridge with a BA in mathematics and a PhD in mathematical modelling of disease progression and has worked for ICNARC since 2002. His main research interests are risk prediction modelling, health technology assessment and evaluation of service delivery and organisation in critical care. David is a Fellow of the Royal Statistical Society and an Honorary Professor in the Department of Medical Statistics at the London School of Hygiene & Tropical Medicine.

Matthew FishMedical Lab Research Assistant

Mathew Fish graduated with a first class honours Degree in Sports and Exercise Science at Leeds Beckett University in 2015 whereby he first developed an interest in elite athlete physiology and exercise physiology. He completed his Master of Science with merit in Human and Applied Physiology at Kings College London in 2017. During this time he focused on the p38 mitogen activated protein kinase pathway in heart failure at the Rayne institute. From this he has a keen interest in the pathophysiology of disease from a molecular level to whole body physiology, in particular cardiovascular disease and the role of the immune system.

Joanne Palmer-JoyceTrial Manager

Joanne Palmer is a Senior Clinical Trials Manager who works with researchers to set up and deliver clinical research in the NHS.
After working for over a decade in the field, Joanne has experience of working across a variety of therapeutic areas and clinical trial phases, with a particular interest in advanced therapeutics and experimental medicine.
Joanne joined Guys and St Thomas’ NHS Foundation Trust in 2017 to lead the Biomedical Research Council Clinical Trial Management Research Platform, which supports clinical trials of high translational value in areas of high unmet need.
Joanne has a degree in Chemistry, and an MPhil in Translational Medicine and Therapeutics. Joanne is also an accredited project manager.