2018 BRC clinical training|Biomedical Research Centre

BRC Clinical Training Fellow 2018

This call for Clinical Training Fellowships (CTFs) is one of several training programmes funded by the BRC and overseen by the BRC Training Cluster STEM. Specifically, we seek to appoint trainees to undertake one year of protected research training in areas closely aligned to BRC focussed research clusters and their themes. It is anticipated that during the period of the CTF successful candidates will be expected to 1) complete core training modules in Translational and Experimental Medicine, 2) actively pursue their research project and 3) prepare a research fellowship application for submission to an external funding body, such as a Research Council, Charity or NIHR to support further training towards a PhD during the tenure of the Fellowship.

The scheme is open to clinical trainees from across the UK who have had, until now, a significant clinical and training commitment that has not allowed them the protected time to develop their research careers. Candidates should have:

Relevant professional qualification or degree with distinction/honours
Registration with relevant professional body
Eligibility and experience at a level appropriate for registering for a higher degree (eg MRes and PhD)

In addition candidates should demonstrate a track record of publications in peer-reviewed journals, in addition to educational achievement and a commitment to an academic career. This fellowship is open to EU and Home students only.

** THIS CALL IS NOW CLOSED. There will be no more this year. The next round will be in 2019 **

The full list of available projects can be found below. Informal enquiries about CTF projects should be addressed to the designated project supervisor.

Supervisor	Project Title	Theme/s	Cluster
Professor Vicky Goh	1. Developing novel imaging biomarkers to improve characterisation of small renal masses (SRMs) by computational analysis and multi-scale modelling of multi-parametric MRI	Imaging Sciences	Cluster 2 – Biomarkers, Co-diagnostics, Imaging and Devices
Professor Aldo Rinaldi	2. Identifying Left Ventricular Perfusion Defects Using CT Scanning to Aid Cardiac Resynchronisation	Cardiovascular disease/ Imaging Sciences	Cluster 2 – Biomarkers, Co-diagnostics, Imaging and Devices
Professor Nicholas Luscombe – based at the Crick institute	3. Genomic assessment of DNA damage in skin cancers	Cutaneous Medicine	Cluster 1 – Experimental Medicine and Therapeutics
Mr Bijan Modarai	4. A study of the collateral circulation in the critically ischaemic limb	Cardiovascular disease/ Imaging Sciences	Cluster 1 – Experimental Medicine and Therapeutics
Professor Catherine Williamson	5. Impact of cholestasis on susceptibility to potentially fatal fetal arrhythmia.	Women & Children’s Health	Cluster 2 – Biomarkers, Co-diagnostics, Imaging and Devices
Professor Graham Lord	6. Regulatory T cells in IBD – understanding the dysfunction and optimising their therapeutic potential	Regenerative Medicine and Cellular Therapy	Cluster 1 – Experimental Medicine and Therapeutics
Professor David Edwards	7. Machine learning and Imaging-Genomics to discover neuroprotective therapies for vulnerable newborn infants	Imaging Sciences/ Women’s and Children’s Health	Cluster 3 – Clinical Informatics
Dr Matthias Krause	8. Investigating the role of the protein Lamellipodin in pancreatic cancer progression.	Imaging Sciences	Cluster 2 – Biomarkers, Co-diagnostics, Imaging and Devices
Dr Stephen Till	9. Investigation of Local Immunoglobulin Expression in Eosinophilic Oesophagitis	Immunity & Infection	Cluster 2 – Biomarkers, Co-diagnostics, Imaging and Devices
Professor Alberto Sanchez Fueyo	10. Immune responses in end stage liver disease and the effect of liver transplantation	Transplantation/ Immunity and Infection	Cluster 2 – Biomarkers, Co-diagnostics, Imaging and Devices
Professor Anthony Dorling	11. Regulatory T cells in Highly Sensitised Renal Patients to Improve Outcomes after HLA-Antibody Incompatible Transplantation.	Transplantation/ Immunity and infection	Cluster 1 – Experimental Medicine and Therapeutics
Dr Alexandra Figueira Santos	12. Regulatory T cells and regulation of gene expression in food allergy	Women & Children’s Health/ Immunity & Infection	Cluster 2 – Biomarkers, Co-diagnostics, Imaging and Devices
Dr Nick Powell	13. Unravelling the cellular and molecular drivers of immune-checkpoint inhibitor induced colitis	Immunity & Infection	Cluster 1 – Experimental Medicine and Therapeutics
Dr Marlies Ostermann	14. Identification of biomarkers and evaluation of immune function in patients with acute kidney injury	Transplantation	Cluster 2 – Biomarkers, Co-diagnostics, Imaging and Devices
Dr Manu Shankar-Hari	15. Acute myocardial dysfunction in sepsis	Immunity & Infection/ Cardiovascular disease	Cluster 2 – Biomarkers, Co-diagnostics, Imaging and Devices
Dr Rocio T Martinez-Nunez	16. Using Frac-seq to assess Mepolizumab and corticosteroid responses in patients with severe asthma	Genomic Medicine/ Immunity and Infection	Cluster 2 – Biomarkers, Co-diagnostics, Imaging and Devices
Dr Francesca Capon	17. The therapeutic potential of IL-17 inhibition in palmar plantar pustulosis	Cutaneous Medicine/ Genomic Medicine/ Immunity and Infection	Cluster 2 – Biomarkers, Co-diagnostics, Imaging and Devices
Dr Debbie Shawcross	18. The faecal microbiome as a therapeutic target for restoring innate immunity in cirrhosis	Immunity & Infection	Cluster 1 – Experimental Medicine and Therapeutics
Dr Esperanza Perucha	19. Does the status of the cholesterol biosynthesis pathway directly regulate host immunity?	Immunity & Infection	Cluster 1 – Experimental Medicine and Therapeutics
Professor Laura A. Magee	20. Biomarker-guided timing of delivery in placental disorders	Women & Children’s Health	Cluster 2 – Biomarkers, Co-diagnostics, Imaging and Devices
Dr Kuberan Pushparajah	21. Antenatal effects of altered circulation and cerebral perfusion in congenital heart disease on perinatal brain development	Imaging Sciences/ Women & Children’s health/ Cardiovascular disease	Cluster 2 – Biomarkers, Co-diagnostics, Imaging and Devices

Professor Divaka Perera	23. Establishing invasive physiological thresholds for ischaemia in left main coronary artery disease.	Cardiovascular disease/ Imaging Sciences.	Cluster 2 – Biomarkers, Co-diagnostics, Imaging and Devices

Dr Claire Steves	25. Detection of early liver fibrosis	Imaging Sciences/ Genomic medicine	Cluster 2 – Biomarkers, Co-diagnostics, Imaging and Devices
Dr Joerg Steier	26. The effect of bariatric surgery on changes in ventilation associated with morbid obesity and improvement in hypercapnic respiratory failure	Cardiovascular disease	Cluster 1 – Experimental Medicine and Therapeutics
Dr Rachel Tribe	27. Improving early pregnancy prediction of spontaneous preterm birth	Women & Children’s Health	Cluster 2 – Biomarkers, Co-diagnostics, Imaging and Devices
Dr Karen Liu	28. Establishing a differentiation pipeline using patient-specific human induced pluripotent stem cells (hiPSCs) to model candidate neurocristopathy genes via CRISPR/Cas9 gene editing	Genomic Medicine/ Oral Health	Cluster 2 – Biomarkers, Co-diagnostics, Imaging and Devices
Professor Anthony Dorling	29. Evaluating the role of coagulation protease-mediated signalling in the development of renal fibrosis.	Transplantation	Cluster 1 – Experimental Medicine and Therapeutics
Dr Louise Izatt	31. Investigation of genetic and epigenetic marks in cancer	Genomic Medicine	Cluster 2 – Biomarkers, Co-diagnostics, Imaging and Devices
Dr Michael Robson	Monocyte and macrophage targeted therapy in autoimmune disease	Immunity & Infection/ Transplantation	Cluster 1 – Experimental Medicine and Therapeutics
Professor Graham Lord	Validation of Biological Targets based on Bioinformatic Analyses derived from the NIHR HIC and UKIRTC National Cohorts	Transplantation	Cluster 2 – Biomarkers, Co-diagnostics, Imaging and Devices

Clinical Research Training Fellowships

Professor Andrew Cope speaks to BRC clinical training fellows Lucy Durham and Natasha Hezelgrave about the one year fellowship.