BRC Clinical Training Fellow 2018

This call for Clinical Training Fellowships (CTFs) is one of several training programmes funded by the BRC and overseen by the BRC Training Cluster STEM.  Specifically, we seek to appoint trainees to undertake one year of protected research training in areas closely aligned to BRC focussed research clusters and their themes.  It is anticipated that during the period of the CTF successful candidates will be expected to 1) complete core training modules in Translational and Experimental Medicine, 2) actively pursue their research project and 3) prepare a research fellowship application for submission to an external funding body, such as a Research Council, Charity or NIHR to support further training towards a PhD during the tenure of the Fellowship.

The scheme is open to clinical trainees from across the UK who have had, until now, a significant clinical and training commitment that has not allowed them the protected time to develop their research careers.  Candidates should have:

  • Relevant professional qualification or degree with distinction/honours
  • Registration with relevant professional body
  • Eligibility and experience at a level appropriate for registering for a higher degree (eg MRes and PhD)

In addition candidates should demonstrate a track record of publications in peer-reviewed journals, in addition to educational achievement and a commitment to an academic career.  This fellowship is open to EU and Home students only.

** THIS CALL IS NOW CLOSED.  There will be no more this year.  The next round will be in 2019 **

The full list of available projects can be found below.  Informal enquiries about CTF projects should be addressed to the designated project supervisor.

Supervisor Project Title Theme/s Cluster

Professor Vicky Goh

1. Developing novel imaging biomarkers to improve characterisation of small renal masses (SRMs) by computational analysis and multi-scale modelling of multi-parametric MRI

Imaging Sciences

Cluster 2 – Biomarkers, Co-diagnostics, Imaging and Devices

Professor Aldo Rinaldi

2. Identifying Left Ventricular Perfusion Defects Using CT Scanning to Aid Cardiac Resynchronisation

Cardiovascular disease/ Imaging Sciences

Cluster 2 – Biomarkers, Co-diagnostics, Imaging and Devices

Professor Nicholas Luscombe – based at the Crick institute

3. Genomic assessment of DNA damage in skin cancers

Cutaneous Medicine

Cluster 1 – Experimental Medicine and Therapeutics

Mr Bijan Modarai

4. A study of the collateral circulation in the critically ischaemic limb

Cardiovascular disease/ Imaging Sciences

Cluster 1 – Experimental Medicine and Therapeutics

Professor Catherine Williamson

5. Impact of cholestasis on susceptibility to potentially fatal fetal arrhythmia.

Women & Children’s Health

Cluster 2 – Biomarkers, Co-diagnostics, Imaging and Devices

Professor Graham Lord

6. Regulatory T cells in IBD – understanding the dysfunction and optimising their therapeutic potential

Regenerative Medicine and Cellular Therapy

Cluster 1 – Experimental Medicine and Therapeutics

Professor David Edwards

7. Machine learning and Imaging-Genomics to discover neuroprotective therapies for vulnerable newborn infants

Imaging Sciences/ Women’s and Children’s Health

Cluster 3 – Clinical Informatics

Dr Matthias Krause

8. Investigating the role of the protein Lamellipodin in pancreatic cancer progression.

Imaging Sciences

Cluster 2 – Biomarkers, Co-diagnostics, Imaging and Devices

Dr Stephen Till

9. Investigation of Local Immunoglobulin Expression in Eosinophilic Oesophagitis

Immunity & Infection

Cluster 2 – Biomarkers, Co-diagnostics, Imaging and Devices

Professor Alberto Sanchez Fueyo

10.  Immune responses in end stage liver disease and the effect of liver transplantation

Transplantation/ Immunity and Infection

Cluster 2 – Biomarkers, Co-diagnostics, Imaging and Devices

Professor Anthony Dorling

11. Regulatory T cells in Highly Sensitised Renal Patients to Improve Outcomes after HLA-Antibody Incompatible Transplantation.

Transplantation/ Immunity and infection

Cluster 1 – Experimental Medicine and Therapeutics

Dr Alexandra Figueira Santos

12. Regulatory T cells and regulation of gene expression in food allergy

Women & Children’s Health/ Immunity & Infection

Cluster 2 – Biomarkers, Co-diagnostics, Imaging and Devices

Dr Nick Powell

13. Unravelling the cellular and molecular drivers of immune-checkpoint inhibitor induced colitis

Immunity & Infection

Cluster 1 – Experimental Medicine and Therapeutics

Dr Marlies Ostermann

14. Identification of biomarkers and evaluation of immune function in patients with acute kidney injury

Transplantation

Cluster 2 – Biomarkers, Co-diagnostics, Imaging and Devices

Dr Manu Shankar-Hari

15. Acute myocardial dysfunction in sepsis

Immunity & Infection/ Cardiovascular disease

Cluster 2 – Biomarkers, Co-diagnostics, Imaging and Devices

Dr Rocio T Martinez-Nunez

16. Using Frac-seq to assess Mepolizumab and corticosteroid responses in patients with severe asthma

Genomic Medicine/ Immunity and Infection

Cluster 2 – Biomarkers, Co-diagnostics, Imaging and Devices

Dr Francesca Capon

17. The therapeutic potential of IL-17 inhibition in palmar plantar pustulosis

Cutaneous Medicine/ Genomic Medicine/ Immunity and Infection

Cluster 2 – Biomarkers, Co-diagnostics, Imaging and Devices

Dr Debbie Shawcross

18. The faecal microbiome as a therapeutic target for restoring innate immunity in cirrhosis

Immunity & Infection

Cluster 1 – Experimental Medicine and Therapeutics

Dr Esperanza Perucha

19. Does the status of the cholesterol biosynthesis pathway directly regulate host immunity?

Immunity & Infection

Cluster 1 – Experimental Medicine and Therapeutics

Professor Laura A. Magee

20. Biomarker-guided timing of delivery in placental disorders

Women & Children’s Health

Cluster 2 – Biomarkers, Co-diagnostics, Imaging and Devices

Dr Kuberan Pushparajah

21. Antenatal effects of altered circulation and cerebral perfusion in congenital heart disease on perinatal brain development

Imaging Sciences/ Women & Children’s health/ Cardiovascular disease

Cluster 2 – Biomarkers, Co-diagnostics, Imaging and Devices

Professor Divaka Perera

23. Establishing invasive physiological thresholds for ischaemia in left main coronary artery disease.

 

Cardiovascular disease/ Imaging Sciences.

Cluster 2 – Biomarkers, Co-diagnostics, Imaging and Devices

Dr Claire Steves

25. Detection of early liver fibrosis

Imaging Sciences/ Genomic medicine

Cluster 2 – Biomarkers, Co-diagnostics, Imaging and Devices

Dr Joerg Steier

26. The effect of bariatric surgery on changes in ventilation associated with morbid obesity and improvement in hypercapnic respiratory failure

Cardiovascular disease

Cluster 1 – Experimental Medicine and Therapeutics

Dr Rachel Tribe

27. Improving early pregnancy prediction of spontaneous preterm birth

Women & Children’s Health

Cluster 2 – Biomarkers, Co-diagnostics, Imaging and Devices

Dr Karen Liu

28. Establishing a differentiation pipeline using patient-specific human induced pluripotent stem cells (hiPSCs) to model candidate neurocristopathy genes via CRISPR/Cas9 gene editing

Genomic Medicine/ Oral Health

Cluster 2 – Biomarkers, Co-diagnostics, Imaging and Devices

Professor Anthony Dorling

29. Evaluating the role of coagulation protease-mediated signalling in the development of renal fibrosis.

Transplantation

Cluster 1 – Experimental Medicine and Therapeutics

Dr Louise Izatt

31. Investigation of genetic and epigenetic marks in cancer

Genomic Medicine

Cluster 2 – Biomarkers, Co-diagnostics, Imaging and Devices

Dr Michael Robson

Monocyte and macrophage targeted therapy in autoimmune disease 

Immunity & Infection/ Transplantation

Cluster 1 – Experimental Medicine and Therapeutics

Professor Graham Lord

Validation of Biological Targets based on Bioinformatic Analyses derived from the NIHR HIC and UKIRTC National Cohorts

Transplantation

Cluster 2 – Biomarkers, Co-diagnostics, Imaging and Devices

Clinical Research Training Fellowships

Professor Andrew Cope speaks to BRC clinical training fellows Lucy Durham and Natasha Hezelgrave about the one year fellowship.